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The Role of Measured Covariates in Assessing Sensitivity to Unmeasured Confounding

Abhinandan Dalal, Iris Horng, Yang Feng, Dylan S. Small

arXiv 16 Feb 2026 · Statistics — Methodology

arXiv:2602.14414 · PDF · DOI · OpenAlex · Extracted main text

Abstract

Sensitivity analysis is widely used to assess the robustness of causal conclusions in observational studies, yet its interaction with the structure of measured covariates is often overlooked. When latent confounders cannot be directly adjusted for and are instead controlled using proxy variables, strong associations between exposure and measured proxies can amplify sensitivity to residual confounding. We formalize this phenomenon in linear regression settings by showing that a simple ratio involving the exposure model coefficient and residual exposure variance provides an observable measure of this increased sensitivity. Applying our framework to smoking and lung cancer, we document how growing socioeconomic stratification in smoking behavior over time leads to heightened sensitivity to unmeasured confounding in more recent data. These results highlight the importance of multicollinearity when interpreting sensitivity analyses based on proxy adjustment.

Citation extraction

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Most heavily cited references

The works this paper leans on most, across its whole bibliography — not restricted to papers in our corpus. Ranked by composite intensity, which combines how often a work is mentioned, how many sections mention it, and how much of that falls in the main text rather than the appendix.

ReferenceIntensityMentionsSectionsMain text
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3Chetty, Raj and Friedman, John N and Hilger, Nathaniel and Saez, Emm… (2011) How does your kindergarten classroom affect your earnings? Evidence from Project STAR0.40511100%
4Cinelli, Carlos and Hazlett, Chad (2020) Making sense of sensitivity: Extending omitted variable bias0.40511100%
5Coleman, James (1968) The concept of equality of educational opportunity0.40511100%
6Cornfield, Jerome and Haenszel, William and Hammond, E Cuyler and Li… (1959) Smoking and lung cancer: recent evidence and a discussion of some questions0.40511100%
7Di Novi, Cinzia and Marenzi, Anna (2019) The smoking epidemic across generations, genders, and educational groups: A matter of diffusion of innovations0.40511100%
8Farrar, Donald E and Glauber, Robert R (1967) Multicollinearity in regression analysis: the problem revisited0.40511100%
9Garrett, Bridgette E and Martell, Brandi N and Caraballo, Ralph S an… (2019) Socioeconomic differences in cigarette smoking among sociodemographic groups0.40511100%
10Goldberger, Arthur Stanley (1991) A course in econometrics0.40511100%

Showing the top 10 of 25 scored citations.