arXiv 7 Nov 2025 · Econometrics
arXiv:2511.04957 · PDF · DOI · OpenAlex · Extracted main text
As predictive algorithms grow in popularity, using the same dataset to both train and test a new model has become routine across research, policy, and industry. Sample-splitting attains valid inference on model properties by using separate subsamples to estimate the model and to evaluate it. However, this approach has two drawbacks, since each task uses only part of the data, and different splits can lead to widely different estimates. Averaging across multiple splits, I develop an inference approach that uses more data for training, uses the entire sample for testing, and improves reproducibility. I address the statistical dependence from reusing observations across splits by proving a new central limit theorem for a large class of split-sample estimators under arguably mild and general conditions. Importantly, I make no restrictions on model complexity or convergence rates. I show that confidence intervals based on the normal approximation are valid for many applications, but may undercover in important cases of interest, such as comparing the performance between two models. I develop a new inference approach for such cases, explicitly accounting for the dependence across splits. Moreover, I provide a measure of reproducibility for p-values obtained from split-sample estimators. Finally, I apply my results to two important problems in development and public economics: predicting poverty and learning heterogeneous treatment effects in randomized experiments. I show that my inference approach with repeated cross-fitting achieves better power than existing alternatives, often enough to reveal statistical significance that would otherwise be missed.
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The works this paper leans on most, across its whole bibliography — not restricted to papers in our corpus. Ranked by composite intensity, which combines how often a work is mentioned, how many sections mention it, and how much of that falls in the main text rather than the appendix.
| Reference | Intensity | Mentions | Sections | Main text | |
|---|---|---|---|---|---|
| 1 | Ritzwoller, David M and Romano, Joseph P (2023) Reproducible aggregation of sample-split statistics | 1.000 | 7 | 3 | 100% |
| 2 | Wager, Stefan (2024) Sequential Validation of Treatment Heterogeneity | 1.000 | 6 | 3 | 100% |
| 3 | Luedtke, Alexander R and Van Der Laan, Mark J (2016) Statistical inference for the mean outcome under a possibly non-unique optimal treatment strategy | 1.000 | 5 | 4 | 100% |
| 4 | Victor Chernozhukov AND Mert Demirer AND Esther Duflo AND Iván Ferná… (2025) Fisher–Schultz Lecture: Generic Machine Learning Inference on Heterogeneous Treatment Effects in Randomized Experiments, With an… | 0.971 | 12 | 6 | 92% |
| 5 | Chernozhukov, Victor and Chetverikov, Denis and Demirer, Mert and Du… (2018) Double/debiased machine learning for treatment and structural parameters | 0.956 | 8 | 3 | 88% |
| 6 | Chernozhukov, Victor and Demirer, Mert and Duflo, Esther and Fernánd… (2025) Reply to: Comments on “Fisher–Schultz Lecture: Generic Machine Learning Inference on Heterogeneous Treatment Effects in Randomiz… | 0.928 | 4 | 3 | 100% |
| 7 | Imai, Kosuke and Li, Michael Lingzhi (2025) Statistical inference for heterogeneous treatment effects discovered by generic machine learning in randomized experiments | 0.928 | 4 | 3 | 100% |
| 8 | Karlan, Dean and List, John A (2007) Does price matter in charitable giving? Evidence from a large-scale natural field experiment | 0.928 | 4 | 3 | 100% |
| 9 | Gasparin, Matteo and Wang, Ruodu and Ramdas, Aaditya (2025) Combining exchangeable p-values | 0.843 | 3 | 3 | 100% |
| 10 | Robert Osei and Isaac Osei-Akoto and Ernest Aryeetey and Fred Dzanku… (2022) ISSER-Northwestern-Yale Long Term Ghana Socioeconomic Panel Survey (GSPS) | 0.843 | 3 | 3 | 100% |
Showing the top 10 of 56 scored citations.
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