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Causal Inference in Counterbalanced Within-Subjects Designs

Justin Ho, Jonathan Min

arXiv 6 May 2025 · Statistics — Methodology

arXiv:2505.03937 · PDF · DOI · OpenAlex · Extracted main text

Abstract

Experimental designs are fundamental for estimating causal effects. In some fields, within-subjects designs, which expose participants to both control and treatment at different time periods, are used to address practical and logistical concerns. Counterbalancing, a common technique in within-subjects designs, aims to remove carryover effects by randomizing treatment sequences. Despite its appeal, counterbalancing relies on the assumption that carryover effects are symmetric and cancel out, which is often unverifiable a priori. In this paper, we formalize the challenges of counterbalanced within-subjects designs using the potential outcomes framework. We introduce sequential exchangeability as an additional identification assumption necessary for valid causal inference in these designs. To address identification concerns, we propose diagnostic checks, the use of washout periods, and covariate adjustments, and alternative experimental designs to counterbalanced within-subjects design. Our findings demonstrate the limitations of counterbalancing and provide guidance on when and how within-subjects designs can be appropriately used for causal inference.

Citation extraction

23
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in-text mentions
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appendix boundary found by appendix_titled_section at “Appendix” · 82% of the source is main text. Read the extracted text to check this.

Most heavily cited references

The works this paper leans on most, across its whole bibliography — not restricted to papers in our corpus. Ranked by composite intensity, which combines how often a work is mentioned, how many sections mention it, and how much of that falls in the main text rather than the appendix.

ReferenceIntensityMentionsSectionsMain text
1Clifford, S., G. Sheagley, and S. Piston (2021) Increasing precision without altering treatment effects: Repeated measures designs in survey experiments0.87462100%
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5Lane, J. N., L. Boussioux, C. Ayoubi, Y. H. Chen, C. Lin, R. Spens,… (2024) The narrative ai advantage? a field experiment on generative ai-augmented evaluations of early-stage innovations0.51121100%
6Tamura, R. N., X. Huang, and D. D. Boos (2011) Estimation of treatment effect for the sequential parallel design0.40511100%
7Whitehead, J., Y. Desai, and T. Jaki (2020) Estimation of treatment effects following a sequential trial of multiple treatments0.40511100%
8Zhou, Q., P. A. Ernst, K. L. Morgan, D. B. Rubin, and A. Zhang (2018) Sequential rerandomization0.40511100%
9Charness, G., U. Gneezy, and M. A. Kuhn (2012) Experimental methods: Between-subject and within-subject design0.40511100%
10Imai, K., L. Keele, and D. Tingley (2010) A general approach to causal mediation analysis0.40511100%

Showing the top 10 of 23 scored citations.