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Synthetic Combinations: A Causal Inference Framework for Combinatorial Interventions

Abhineet Agarwal, Anish Agarwal, Suhas Vijaykumar

arXiv 24 Mar 2023 · Statistics — Methodology

arXiv:2303.14226 · PDF · DOI · OpenAlex · Extracted main text

Abstract

Consider a setting where there are $N$ heterogeneous units and $p$ interventions. Our goal is to learn unit-specific potential outcomes for any combination of these $p$ interventions, i.e., $N \times 2^p$ causal parameters. Choosing a combination of interventions is a problem that naturally arises in a variety of applications such as factorial design experiments, recommendation engines, combination therapies in medicine, conjoint analysis, etc. Running $N \times 2^p$ experiments to estimate the various parameters is likely expensive and/or infeasible as $N$ and $p$ grow. Further, with observational data there is likely confounding, i.e., whether or not a unit is seen under a combination is correlated with its potential outcome under that combination. To address these challenges, we propose a novel latent factor model that imposes structure across units (i.e., the matrix of potential outcomes is approximately rank $r$), and combinations of interventions (i.e., the coefficients in the Fourier expansion of the potential outcomes is approximately $s$ sparse). We establish identification for all $N \times 2^p$ parameters despite unobserved confounding. We propose an estimation procedure, Synthetic Combinations, and establish it is finite-sample consistent and asymptotically normal under precise conditions on the observation pattern. Our results imply consistent estimation given $poly(r) \times \left( N + s^2p\right)$ observations, while previous methods have sample complexity scaling as $\min(N \times s^2p, \ \ poly(r) \times (N + 2^p))$. We use Synthetic Combinations to propose a data-efficient experimental design. Empirically, Synthetic Combinations outperforms competing approaches on a real-world dataset on movie recommendations. Lastly, we extend our analysis to do causal inference where the intervention is a permutation over $p$ items (e.g., rankings).

Citation extraction

63
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106
in-text mentions
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distinct cited
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main-text words

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Most heavily cited references

The works this paper leans on most, across its whole bibliography — not restricted to papers in our corpus. Ranked by composite intensity, which combines how often a work is mentioned, how many sections mention it, and how much of that falls in the main text rather than the appendix.

ReferenceIntensityMentionsSectionsMain text
1Agarwal, Dahleh, Shah \ Shen (2023) Causal matrix completion, in `The Thirty Sixth Annual Conference on Learning Theory', PMLR, pp. 3821–38260.92843100%
2George, Hunter \ Hunter (2005) Statistics for experimenters: design, innovation, and discovery, Wiley0.84333100%
3Agarwal, Shah \ Shen (2020) `Synthetic interventions', arXiv preprint arXiv:2006.076910.8307357%
4Agarwal, Shah \ Shen (2020) `On principal component regression in a high-dimensional error-in-variables setting', arXiv preprint arXiv:2010.144490.7373367%
5Negahban \ Shah (2012) Learning sparse boolean polynomials, in `2012 50th Annual Allerton Conference on Communication, Control, and Computing (Allerton…0.73732100%
6Syrgkanis \ Zampetakis (2020) Estimation and inference with trees and forests in high dimensions, in `Conference on learning theory', PMLR, pp. 3453–34540.6936333%
7Anish Agarwal \ Song (2021) `On robustness of principal component regression', Journal of the American Statistical Association 116(536), 1731–17450.64422100%
8Bertrand \ Mullainathan (2004) `Are emily and greg more employable than lakisha and jamal? a field experiment on labor market discrimination', American economi…0.64422100%
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10Dasgupta, Pillai \ Rubin (2015) `Causal inference from 2 k factorial designs by using potential outcomes', Journal of the Royal Statistical Society: Series B: S…0.64422100%

Showing the top 10 of 63 scored citations.

Cited by, within the corpus

arXiv econ.EM papers that cite this one, ranked by how heavily they lean on it.

Citing paperIntensityMentionsSections
1Synthetic Interventions0.51121
2Adaptive Principal Component Regression with Applications to Panel Data0.40521
3A Causal Inference Framework for Data Rich Environments0.40511
4Network Synthetic Interventions: A Causal Framework for Panel Data Under Network Interference0.00031